Immunologic Basis and Immunoprophy-laxis of RhD Induced Hemolytic Disease of the Newborn (HDN)
نویسندگان
چکیده مقاله:
RhD antigen is the most immunogenic and clinically significant antigen of red blood cells after ABO system. It has historically been associated with hemolytic disease of the newborn (HDN) which is now routinely prevented by the administration of polyclonal anti-D immunoglobulin. This management of HDN has proven to be one of the most successful cases of prophylactic treatment based on antibody mediated immune sup-pression (AMIS). Despite the increasing efficiency of treatment, the mechanism of ac-tion of anti-D is not completely defined. There is a widespread interest in obtaining a reliable therapeutic monoclonal anti-D, due to difficulty of maintaining a pool of high titer volunteer donors for plasma collection and also increasing demand for antenatal prophylaxis and safety issues with plasma derived products. Candidate monoclonal anti-D preparations should demonstrate appropriate functionality in both in vitro and in vivo assays comparable to polyclonal anti-D immunoglobulin. These criteria are reviewed in addition to the factors regulating development of D specific immune response in D negative individuals and its suppression in HDN prophylaxis.
منابع مشابه
immunologic basis and immunoprophy-laxis of rhd induced hemolytic disease of the newborn (hdn)
rhd antigen is the most immunogenic and clinically significant antigen of red blood cells after abo system. it has historically been associated with hemolytic disease of the newborn (hdn) which is now routinely prevented by the administration of polyclonal anti-d immunoglobulin. this management of hdn has proven to be one of the most successful cases of prophylactic treatment based on antibody ...
متن کاملImmunologic basis and immunoprophylaxis of RhD induced hemolytic disease of the newborn (HDN).
RhD antigen is the most immunogenic and clinically significant antigen of red blood cells after ABO system. It has historically been associated with hemolytic disease of the newborn (HDN) which is now routinely prevented by the administration of polyclonal anti-D immunoglobulin. This management of HDN has proven to be one of the most successful cases of prophylactic treatment based on antibody ...
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Gac Méd Méx Vol. 140, Suplemento No. 3, 2004 Rh haemolytic disease of the fetus and newborn (HDN) is a condition in which the lifespan of the infant’s red cells is shortened by the binding of specific IgG Rh antibodies produced by the mother, which transfer across the placenta. The disease begins in intra-uterine life and shows a wide spectrum of severity. Not all D-positive infants born to mot...
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Hemolytic disease of the newborn (HDN), with high potential for increased fetal loss is less common now, due to the universal screening for iso-sensitization and also because of appropriate use of antenatal anti-RhD antibody prophylaxis. There are other non-RhD antibodies that can cause HDN. In US, we occasionally encounter a highly sensitized fetus with significant morbidity and mortality. In ...
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عنوان ژورنال
دوره 5 شماره 4
صفحات 189- 200
تاریخ انتشار 2008-12-01
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